Which term describes normal programmed cell death in tissues?

Study for the NATA BOC Domain 2 Clinical Evaluation and Diagnosis Special Test. Engage with interactive flashcards and multiple-choice questions, each with hints and detailed explanations. Get ready for your professional assessment!

Multiple Choice

Which term describes normal programmed cell death in tissues?

Explanation:
Apoptosis is the term for normal programmed cell death in tissues. It is a controlled, energy-dependent process that eliminates cells without provoking inflammation, using caspase cascades to cause cell shrinkage, chromatin condensation, DNA fragmentation, and phagocytic clearance of cellular debris. This contrasts with necrosis, where injury causes cell swelling and membrane rupture with an inflammatory response. It also differs from uncontrolled cell growth and chronic inflammation, which are about abnormal proliferation or persistent inflammatory processes, not the orderly removal of cells. So apoptosis best describes normal programmed cell death in tissues.

Apoptosis is the term for normal programmed cell death in tissues. It is a controlled, energy-dependent process that eliminates cells without provoking inflammation, using caspase cascades to cause cell shrinkage, chromatin condensation, DNA fragmentation, and phagocytic clearance of cellular debris. This contrasts with necrosis, where injury causes cell swelling and membrane rupture with an inflammatory response. It also differs from uncontrolled cell growth and chronic inflammation, which are about abnormal proliferation or persistent inflammatory processes, not the orderly removal of cells. So apoptosis best describes normal programmed cell death in tissues.

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